The effects of CYP1A2 and ADORA2A genotypes association with acute caffeine intake on physiological effects and performance: A systematic review

Authors

Rabia Rümeysa KOCATÜRK, Molecular Biology, Institute of Sciences, Üsküdar University, Istanbul, Turkey
İlke KARAGÖZ, Nutrition and Dietetics, Institute of Health Sciences, Üsküdar University, Istanbul, Turkey
Ebru YANIK, Nutrition and Dietetics, Institute of Health Sciences, Üsküdar University, Istanbul, Turkey
Öznur Özge ÖZCAN, Department of Electroneurophysiology, Physiotherapy, Vocational School of Health Services, Üsküdar University, Istanbul, Turkey
Türker Tekin ERGÜZEL, Department of Software Engineering, Faculty of Engineering and Natural Sciences, Istanbul, Turkey
Mesut KARAHAN, Department of Biomedical Device Technology, Vocational School of Health Sciences, Istanbul, Turkey, Üsküdar UniversityFollow
Nevzat TARHAN, Department of Psychiatry, Medical School, Üsküdar University, Istanbul, Turkey / NP Istanbul Brain Hospital, Istanbul, Turkey

Abstract

Introduction: This systematic review aims to examine the effects of the CYP1A2 −163C>A and ADORA2A 1976T>C polymorphism on physiological effects and performance relative to caffeine consumption. Material and Methods: In this study, electronic databases including PubMed, Web of Science Core Collection, Korean Journal Database, Russian Science Citation Index, SciELO Citation Index, Scopus, ScienceDirect, ProQuest Dissertations & Thesis Global and EBSCO were searched. Results: The results highlight that individuals with the TT or CT/CC genotype can have differences in caffeine consumption, and C carriers may have increases in the maximum oxygen uptake (VO₂max). The AA or AC/CC genotypes can have different caffeine consumption and VO₂max. In four studies, TT or CT/CC either in AA or CC genotype had different physiological effects. Regardless of the amount of caffeine (3 mg/kg^-5 mg/kg), Carriers of the C allele in the genotype ADORA2A gene have higher sports performance. Six studies revealed a significant correlation between the AA genotype and performance following caffeine intake. Conclusions: Genotype variations in ADORA2A and CYP1A2 may modulate the ergogenic effects of caffeine, but some physiological effects can occur for different genotypes.

Recommended Citation

Kocaturk RR, Karagoz I, Yanik E , Ozcan OO, Erguzel TT, Karahan M, Tarhan N. The Effects of CYP1A2 and ADORA2A genotypes association with acute caffeine intake on physiological effects and performance: A systematic review. Balt J Health Phys Act. 2022;14(3):Article8. https://doi.org/10.29359/BJHPA.14.3.08

Author ORCID Identifier

Rabia Rümeysa KOCATÜRK ORCID 0000-0001-6769-3057

İlke KARAGÖZ ORCID 0000-0002-3011-4899

Ebru YANIK ORCID 0000-0003-4165-4492

Öznur Özge ÖZCAN ORCID 0000-0001-8992-0556

Türker Tekin ERGÜZEL ORCID 0000-0001-8438-6542

Mesut KARAHAN ORCID 0000-0002-8971-678X

Nevzat TARHAN ORCID 0000-0002-6810-7096

Creative Commons License

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